GMIBIO

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41 篇已發表的 GMI 研究，依研究主題分組。

人體臨床研究 (2)

以人為受試者的臨床研究（前瞻性試驗、先導研究）。證據等級最高，單獨列出。

Effects of Reishimmune-S, a Fungal Immunomodulatory Peptide Supplement, on the Quality of Life and Circulating Natural Killer Cell Profiles of Patients With Early Breast Cancer Receiving Adjuvant Endocrine Therapy
Su, Ying-Wen, Huang, Wen-Yu, Lin, Sheng-Hsiang, 等 — Integrative Cancer Therapies, 2024 · doi:10.1177/15347354241242120
Efficacy of GMI, a fungal immunomodulatory protein, for head and neck cancer patients with chemotherapy-related oral mucositis: An open-labeled prospective single-arm study
Lu, Hsueh-Ju, Li, Che-Hsing, Kang, Yu-Ting, 等 — Medicine, 2022 · doi:10.1097/MD.0000000000029185

癌症 (24)

肺癌、乳癌、頭頸癌等癌別，以及癌幹細胞、抗藥性、轉移與化療副作用（口腔黏膜炎）。

Ganoderma microsporum Immunomodulatory Protein (GMI) Enhances Phagocytosis by Suppressing STAT3/CD47 Signaling in EGFR-Mutant NSCLC Resistant to Gefitinib and Osimertinib
Hsieh, Ya-Chu, Hsin, I.-Lun, Chiu, Ling-Yen, 等 — Journal of Cancer, 2026 · doi:10.7150/jca.124363
Ganoderma Microsporum immunomodulatory protein suppresses osteosarcoma growth through redox imbalance and ER stress-driven apoptosis
Sun, Ying-Sui, Chang, Chi-Jen, Chang, Tsung-Ming, 等 — Bioorganic Chemistry, 2026 · doi:10.1016/j.bioorg.2026.109909
rFIP-GMI Suppresses IGF-1-Induced Invasion and Migration in Breast Cancer Cells via PI3K/Akt/β-Catenin Inhibition
Liao, Wen-Ling, Wu, Yu-Ying, Liu, Yu-Fan, 等 — Drug Development Research, 2025 · doi:10.1002/ddr.70202
GMI, a Fungal Immunomodulatory Protein From Ganoderma microsporum, Induces Different Cytotoxicity in Parental and Osimertinib-Resistant EGFR-Mutated Lung Cancer Cells via Apoptotic and Autophagic Cell Death
Kang, Yu-Ting, Hsin, I.-Lun, Su, Pin-Tzu, 等 — Basic & Clinical Pharmacology & Toxicology, 2025 · doi:10.1111/bcpt.70143
Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1
Hua, Wei-Jyun, Huang, Li-Chen, Lin, Zhi-Hu, 等 — International Journal of Molecular Medicine, 2025 · doi:10.3892/ijmm.2025.5658
Integrin αV Inhibition by GMI, a Ganoderma Microsporum Immunomodulatory Protein, Abolish Stemness and Migration in EGFR-Mutated Lung Cancer Cells Resistant to Osimertinib
Kang, Yu-Ting, Chang, Hui-Yi, Hsieh, Ya-Chu, 等 — Environmental Toxicology, 2024 · doi:10.1002/tox.24399
Ganoderma microsporum immunomodulatory protein combined with KRASG12C inhibitor impedes intracellular AKT/ERK network to suppress lung cancer cells with KRAS mutation
Hua, Wei-Jyun, Hwang, Wei-Lun, Yeh, Hsin, 等 — International Journal of Biological Macromolecules, 2024 · doi:10.1016/j.ijbiomac.2024.129291
GMI, a Ganoderma microsporum protein, abolishes focal adhesion network to reduce cell migration and metastasis of lung cancer
Lo, Hung-Chih, Hua, Wei-Jyun, Yeh, Hsin, 等 — Life Sciences, 2023 · doi:10.1016/j.lfs.2023.122255
Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells
Hua, Wei-Jyun, Yeh, Hsin, Lin, Zhi-Hu, 等 — Cancer Letters, 2023 · doi:10.1016/j.canlet.2023.216458
GMI, Ganoderma microsporum protein, suppresses cell mobility and increases temozolomide sensitivity through induction of Slug degradation in glioblastoma multiforme cells
Tseng, Ai-Jung, Tu, Tsung-Hsi, Hua, Wei-Jyun, 等 — International Journal of Biological Macromolecules, 2022 · doi:10.1016/j.ijbiomac.2022.08.024
Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells
Chiu, Ling-Yen, Hsin, I.-Lun, Tsai, Jen-Ning, 等 — Journal of Cellular Physiology, 2021 · doi:10.1002/jcp.29924
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells
Lin, Tung-Yi, Hua, Wei-Jyun, Yeh, Hsin, 等 — Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2021 · doi:10.1016/j.phymed.2020.153384
CD133 inhibition via autophagic degradation in pemetrexed-resistant lung cancer cells by GMI, a fungal immunomodulatory protein from Ganoderma microsporum
Hsin, I.-Lun, Chiu, Ling-Yen, Ou, Chu-Chyn, 等 — British Journal of Cancer, 2020 · doi:10.1038/s41416-020-0885-8
Inhibition of proliferation and migration of melanoma cells by ketoconazole and Ganoderma immunomodulatory proteins
Lu, Chun-Te, Leong, Pui-Ying, Hou, Ting-Yi, 等 — Oncology Letters, 2019 · doi:10.3892/ol.2019.10355
The Protective Role of GMI, an Immunomodulatory Protein From Ganoderma microsporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis
Li, Che-Hsing, Ko, Jiunn-Liang, Ou, Chu-Chyn, 等 — Integrative Cancer Therapies, 2019 · doi:10.1177/1534735419833795
Ganoderma immunomodulatory protein and chidamide down-regulate integrin-related signaling pathway result in migration inhibition and apoptosis induction
Lu, Chun-Te, Leong, Pui-Ying, Hou, Ting-Yi, 等 — Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2018 · doi:10.1016/j.phymed.2018.06.023
GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells
Hsin, I.-Lun, Hsu, Jen-Chieh, Wu, Wen-Jun, 等 — Environmental Toxicology, 2018 · doi:10.1002/tox.22582
Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells
Huang, Sheng-Yuan, Chien, Chih-Cheng, Hseu, Ruey-Shyang, 等 — Journal of Cellular Biochemistry, 2018 · doi:10.1002/jcb.26616
GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition
Wang, Tung Yuan, Yu, Cheng-Chia, Hsieh, Pei-Ling, 等 — Oncotarget, 2017 · doi:10.18632/oncotarget.19711
Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells
Chiu, Ling-Yen, Hu, Ming-E., Yang, Tsung-Ying, 等 — PloS One, 2015 · doi:10.1371/journal.pone.0125774
GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells
Hsin, I.-Lun, Ou, Chu-Chyn, Wu, Ming-Fang, 等 — Molecular Pharmaceutics, 2015 · doi:10.1021/mp500840z
Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum
Hsin, I.-Lun, Sheu, Gwo-Tarng, Jan, Ming-Shiou, 等 — British Journal of Pharmacology, 2012 · doi:10.1111/j.1476-5381.2012.02073.x
GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells
Hsin, I.-Lun, Ou, Chu-Chyn, Wu, Tzu-Chin, 等 — Autophagy, 2011 · doi:10.4161/auto.7.8.15698
A new immunomodulatory protein from <i>Ganoderma microsporum</i> inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells
Lin, Ching-Hsiung, Sheu, Gwo-Tarng, Lin, Yu-Wen, 等 — Process Biochemistry, 2010 · doi:10.1016/j.procbio.2010.06.006

感染與抗病毒 (4)

冠狀病毒（SARS-CoV-2）、EBV、HSV-1 等病毒感染，以及感染相關免疫反應。

Broad-spectrum antiviral activity of Ganoderma microsporum immunomodulatory protein: Targeting glycoprotein gB to inhibit EBV and HSV-1 infections via viral fusion blockage
Vo, Di Ngoc Kha, Ho, Ha Phan Thanh, Wu, Li-Syuan, 等 — International Journal of Biological Macromolecules, 2025 · doi:10.1016/j.ijbiomac.2025.142179
GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway
Lin, Zhi-Hu, Yeh, Hsin, Lo, Hung-Chih, 等 — International Journal of Biological Macromolecules, 2023 · doi:10.1016/j.ijbiomac.2023.124648
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion
Ho, Ha Phan Thanh, Vo, Di Ngoc Kha, Lin, Tung-Yi, 等 — Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2022 · doi:10.1016/j.biopha.2022.113766
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus
Yeh, Hsin, Vo, Di Ngoc Kha, Lin, Zhi-Hu, 等 — Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2022 · doi:10.1016/j.phymed.2022.154215

神經 (3)

神經突生長、脊髓損傷、創傷性腦損傷與神經發炎。

Ganoderma microsporum-derived fungal immunomodulatory protein (GMI) promotes functional recovery after spinal cord injury by modulating anti-inflammation and enhancing regeneration
Tu, Tsung-Hsi, Chen, Ching-Jung, Fay, Li-Yu, 等 — Experimental Neurology, 2026 · doi:10.1016/j.expneurol.2025.115536
Immunomodulatory protein from ganoderma microsporum protects against oxidative damages and cognitive impairments after traumatic brain injury
Chao, Ming-Wei, Liao, Chia-Wei, Lin, Chin-Hung, 等 — Molecular and Cellular Neurosciences, 2022 · doi:10.1016/j.mcn.2022.103735
Anti-inflammatory and Neuroprotective Effects of Fungal Immunomodulatory Protein Involving Microglial Inhibition
Chen, Wen-Ying, Chang, Cheng-Yi, Li, Jian-Ri, 等 — International Journal of Molecular Sciences, 2018 · doi:10.3390/ijms19113678

肌肉與代謝 (2)

肌母細胞分化、肌少症、粒線體恆定與脂質代謝。

Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism
Fann, Yu-Ning, Teo, Wan-Huai, Lee, Hsin-Chen, 等 — Journal of Cachexia, Sarcopenia and Muscle, 2024 · doi:10.1002/jcsm.13549
Ganoderma microsporum immunomodulatory protein, GMI, promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 acetylation
Teo, Wan-Huai, Lo, Jeng-Fan, Fan, Yu-Ning, 等 — PloS One, 2020 · doi:10.1371/journal.pone.0244791

環境壓力與抗氧化 (1)

PM2.5 細懸浮微粒暴露、氧化壓力。

The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings
Tseng, Chia-Yi, Yu, Jia-Yu, Chuang, Yu-Chen, 等 — Scientific Reports, 2019 · doi:10.1038/s41598-019-38810-5

組織修復 (2)

慢性傷口癒合、抗纖維化、牙周炎、幹細胞增殖。

Ganoderma Microsporum Immunomodulatory Protein Alleviates Inflammaging and Oxidative Stress in Diabetes-Associated Periodontitis via Nrf2 Signaling Activation: An In Vitro Study
Su, Ni-Yu, Ng, Min Yee, Liao, Heng-Yi, 等 — Antioxidants, 2024 · doi:10.3390/antiox13070817
Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts
Lee, Ping-Hui, Hsieh, Pei-Ling, Liao, Yi-Wen, 等 — Environmental Toxicology, 2018 · doi:10.1002/tox.22489

免疫調節與抗發炎 (2)

免疫調節、抗發炎，以及未歸入特定疾病的免疫相關研究。

GMI, an Immunomodulatory Peptide from Ganoderma microsporum, Restrains Periprosthetic Joint Infections via Modulating the Functions of Myeloid-Derived Suppressor Cells and Effector T Cells
Peng, Kuo-Ti, Chen, Jiun-Liang, Kuo, Liang-Tseng, 等 — International Journal of Molecular Sciences, 2021 · doi:10.3390/ijms22136854
GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells
Lin, Ching-Hsiung, Hsiao, Yi-Min, Ou, Chu-Chyn, 等 — Journal of Agricultural and Food Chemistry, 2010 · doi:10.1021/jf103068w

平台技術與安全性 (1)

GMI 序列與選殖、單株抗體、外泌體組成物、安全性評估。

Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats
Fu, Hsu-Yuan, Hseu, Ruey-Shyang — Toxicology Reports, 2022 · doi:10.1016/j.toxrep.2022.05.013